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2018, In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats, Archives of Toxicology 92:32073221

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A Closer Look at Kidney Health: Dark urine, especially when accompanied by pain or fever, can be an indicator of kidney stones, which can also be a symptom of urine color and kidney disease

Current research gaps include limited understanding of derivatives long-term safety profiles and metabolic fate